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Description:Vibrator Introduction The process of cytokinesis is the final step of cell division that requires first the constriction of the cell in the equatorial region of the spindle and then abscission of the two daughters. Considerable attention has been focused upon both the establishment of the contractile ring and its constriction. The initiation of constriction leading to formation of the cleavage furrow is mediated by a signalling process that requires the so-called centralspindlin complex. The microtubule cytoskeleton participates in this process not only in the delivery of the signal but also in ensuring the formation and maintenance of the contractile structures. This is achieved through a mutually dependent interaction of the central spindle, an overlapping array of spindle microtubules that forms in late anaphase, with the contractile ring itself Gatti et al.
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